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Special Issue Call for Papers

Advances in Cellular Target Engagement and Target Deconvolution

Update: Proposals will be accepted until March 18!

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SLAS Discovery

SLAS Discovery Guest Editors Martin Main, Ph.D. (Medicines Discovery Catapult) and Andrew Zhang, Ph.D. (AstraZeneca) invite the submission of abstracts on advances in cellular compound-target engagement measurement and application to target deconvolution in drug discovery for publication in a 2020 special issue. Manuscript proposals (abstracts) will be used to select and invite papers for review and publication consideration.

Drs. Main and Zhang seek high-quality, short or full-length research reports, reviews and perspectives related to all methods for monitoring compound-target engagement in cells and for deconvoluting the molecular target of biologically active compounds. Manuscript proposals (abstracts) are welcome from academia, industry and vendors. Areas of particular interest include but are not limited to:

  • Direct measurement of compound-target engagement in cells
  • Analysis of the mechanism and kinetics of compound binding in cells
  • Monitoring cellular target engagement through microscopy and imaging
  • Methods for monitoring compound-target engagement in membrane proteins
  • Target deconvolution through mass spectrometry readouts, including chemical proteomics, CETSA and other orthogonal methods
  • Application of PROTAC technology for target deconvolution and validation
  • Chemical probe design and generation for any of the above applications

Submit your manuscript proposal before March 18, 2019.

  1. Submit a working title and abstract (up to 500 words) as an MSWord document/attachment to
  2. Include “SLAS Discovery Special Issue / TEG” in the subject line of your e-mail.
  3. Include your name, affiliation and contact info in the text of the e-mail and in your MSWord document.

Invited manuscripts will need to be completed and submitted by July 1, 2019. All submitted papers will be subject to peer-review to ensure scientific rigor, clarity of expression and integration with other contributions in the SLAS Technology special issue. Submissions from SLAS members, nonmembers and especially IEEE NANOMED 2018 speakers are welcome. No APCs.

Publication note: After submissions are accepted, they typically publish online ahead-of-print within 30 days and become immediately searchable and citeable with a DOI.

Questions? Please e-mail or call +1.630.256.7527, ext. 105.