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Call for Papers - Hit Discovery Methodology

Proposal deadline extended to January 31!

Submit Proposals Here

SLAS Discovery Guest Editors Peter Hodder, Ph.D., (Executive Director of Discovery Research, Amgen) and Mark Wigglesworth, Ph.D., (Director High Throughput Screening, AstraZeneca) invite the submission of abstracts that describe best-practice implementation of hit discovery technologies for publication in a 2021 Special Issue. Manuscript proposals (abstracts) will be used to select and invite papers for review and publication consideration.

Drs. Hodder and Wigglesworth seek high-quality, short- or full-length research reports, reviews, and perspectives related to impactful screening paradigms, plate-based assay and automation platforms, and related analyses of screening results. Manuscript proposals (abstracts) are welcome from academia, industry, and vendors. Areas of particular interest include, but are not limited to:

  • Application of a toolbox of hit discovery technologies to define valuable hits from which to start optimization.
  • Target-based screening campaigns exemplifying coordination of multiple detection technologies to identify and validate hits
  • Application of biophysical and target engagement platforms to screen and quantify ligand affinity
  • Combination of assays, platforms and data analysis techniques that enable the translation of phenotypic assay screening results into pathway- or target-specific hits
  • Applications of non-traditional small molecule screening paradigms, e.g. DNA-encoded library screening, microfluidic screening technologies, outcomes of AI-, ML- or in silico- based screening campaigns
  • Repurposing of small-molecule screening technologies for other drug discovery modalities (e.g. siRNA, antibody)
  • The impact of different screening library compositions (diverse, target focused, pharmacologically annotated) on the quality of screening hits
  • Novel and future hit identification technologies, especially where they have the potential to revolutionize hit identification paradigms

Submit your manuscript proposal before January 31, 2020. It should include your name, contact information, affiliation, a working title and abstract (250-500 words) as an MS Word document.

Invited manuscripts will need to be completed and submitted by March 31, 2020. All submitted papers will be subject to peer-review to ensure scientific rigor, clarity of expression and integration with other contributions in the SLAS Discovery special issue. Submissions from SLAS members, nonmembers and especially attendees of the Advanced 3D Human Models and High-Content Analysis Symposium, and AI in Process Automation Symposia are welcomed!

Publication note: After submissions are accepted, they typically publish online ahead-of-print within 30 days and become immediately searchable and citable with a DOI.

Questions? Please e-mail or call +1.630.256.7527, ext. 106.