SLAS Discovery Guest Editor Jayme L. Dahlin, M.D., Ph.D., (Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School) invites the submission of manuscript proposals (abstracts) for publication in a 2021 special issue. Abstracts will be used to select and invite papers for review and publication consideration.
Dr. Dahlin seeks high-quality, short- or full-length research reports, reviews, case reports and perspectives related to approaches for prioritizing high-quality chemical matter in chemical probe and drug discovery. Abstracts are welcome from academia, industry and vendors. Areas of particular interest include but are not limited to:
Strategies in assay design for increasing hit quality in chemical probe and drug discovery:
Reagents and experimental design approaches for enhancing assay quality and reducing compound interferences
Ccreening library design and mechanism of action/informer sets
Experimental approaches for reducing frequent hitters/nuisance compounds
Compound management and automation practices for increasing assay robustness and hit quality
HTS triage and hit prioritization in chemical probe and drug discovery:
Novel metrics for quantifying compound “quality"
Statistical approaches for correcting random and systematic errors in HTS and HCS data
Cheminformatics approaches to flag undesirable chemical matter or compound prioritization
Screening tree/workflow design
Novel analyses of large-scale HTS datasets
Novel counter-screens for assay interferences
Tools and strategies to aid in targeted covalent inhibitor discovery
Experimental and computational approaches to assessing target selectivity of compounds
Analytical chemistry support in HTS follow-up
Biophysical approaches for characterizing target engagement
Case reports describing the triage of poorly tractable chemical matter or de-risking of “risky” or “imperfect” screening hits or
Perspectives describing personal or institutional approaches to compound prioritization. (e.g., “How I pick compounds after a high-throughput screen," or “How we follow-up on high-throughput screening hits")
Submit your manuscript proposalbefore July 1, 2020. Proposals should include your name, contact information, affiliation, a working title and abstract (250-500 words) as an MS Word document.
Invited manuscripts will need to be completed and submitted by December 1, 2020. All submitted papers will be subject to peer-review to ensure scientific rigor, clarity of expression and integration with other contributions in the SLAS Discovery Special Issue.
Publication note: After submissions are accepted, they typically publish online ahead-of-print within 30 days and become immediately searchable and citable with a DOI.
Manuscript type note: SLAS is adding case reports as a manuscript type for this special issue:
A case report is recommended for the brief description of significant technical challenges and their corresponding solutions in assay design and implementation. Example content can include but is not limited to:
descriptions of elusive mechanisms of a compound-, reagent- or consumable-mediated assay interference,
artifacts due to automation or instrumentation and
adjustments to assay design or data analyses that had significant impacts on assay performance.
Case reports should contain an abstract, a brief introduction, a methods section, combined results and discussion section, two figures/tables and up to 10 references. It should contain less than 2,500 words, however, authors may include supplementary materials including extended methods description, additional data, etc.