The Latest issue of SLAS Technology offers research in Skin Cutaneous Melanoma Prognosis, Nanoliter Droplet Handling for Enhanced Laboratory Efficiency and other areas of life science technology.
Oak Brook, IL (March 15, 2024) – Volume 29, Issue 1 of SLAS Technology, includes five original research articles covering skin cutaneous melanoma, glycan-bead coupling and acoustic ejection mass spectrometry, along with an editorial highlighting the latest in life sciences discovery and technology.
Original Research
- Identification of m6A-Related lncRNAs-Based Signature for Predicting the Prognosis of Patients with Skin Cutaneous Melanoma
This study identifies 98 long non-coding RNAs (lncRNAs) associated with N6-methyladenosine (m6A) RNA modification in skin cutaneous melanoma (SKCM) tissues, which are used to develop a prognostic signature (m6A-LPS). The m6A-LPS demonstrated high predictive accuracy for patient survival.
- Automated Glycan-Bead Coupling for High-Throughput, Highly Reproducible Anti-Glycan Antibody Analysis
This study presents an automated protocol for conjugating glycans to color-coded magnetic beads, facilitating the detection of anti-glycan antibodies across different species and isotypes. This method allows for high-throughput screening of monoclonal antibodies and prediction of treatment response or disease outcomes based on anti-glycan antibody profiles in human body fluids, offering a scalable and versatile approach for various laboratory applications.
- A High-Throughput Quality Control Method for Assessing the Serial Dilution Performance of Dose–Response Plates with Acoustic Ejection Mass Spectrometry
The authors introduce an acoustic ejection mass spectrometry (AEMS) method for rapidly and accurately evaluating the quality of automated liquid handler performance in generating dilutions for dos-response plates. Their method overcomes the limitations of traditional techniques and supports high-throughput screening with precise and label-free data acquisition.
- Automated Measurement of Transepithelial Electrical Resistance (TEER) in 96-Well Transwells Using ECIS TEER96: Single and Multiple Time Point Assessments
The ECIS TEER96 device offers continuous and accurate measurements of transepithelial electrical resistance (TEER) across a wide range of values, providing valuable insights into cellular behavior in vitro. Its convenience and reliability make it a promising tool for drug permeability assays, inflammation studies, and understanding disease states in cell culture systems.
- ANDeS: An Automated Nanoliter Droplet Selection and Collection Device
The Automated Nanoliter Droplet Selection device (ANDeS) enables automated collection and transfer of nanoliter samples from Droplet Microarrays (DMA), addressing the challenge of handling small volumes in high-throughput biological and chemical applications. ANDeS offers precise volume collection and transfer, enhancing the versatility of DMA platforms and expanding possibilities for miniaturized assays in fields such as cell screening, omics analysis, and combinatorial chemistry.
Editorial
- Life Sciences Discovery and Technology Highlights
This editorial examines areas of life science technology research such as advances in biotechnology, artificial intelligence in science, advances in nanotechnology and machine learning for cross-scale microscopy of viruses.
This issue of SLAS Technology is available at https://slas-technology.org/issue/S2472-6303(24)X0002-3
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SLAS Technology reveals how scientists adapt technological advancements for life sciences exploration and experimentation in biomedical research and development. The journal emphasizes scientific and technical advances that enable and improve:
- Life sciences research and development
- Drug delivery
- Diagnostics
- Biomedical and molecular imaging
- Personalized and precision medicine
SLAS (Society for Laboratory Automation and Screening) is an international professional society of academic, industry and government life sciences researchers and the developers and providers of laboratory automation technology. The SLAS mission is to bring together researchers in academia, industry and government to advance life sciences discovery and technology via education, knowledge exchange and global community building.
SLAS Technology: Translating Life Sciences Innovation, 2022 Impact Factor 2.7. Editor-in-Chief Edward Kai-Hua Chow, Ph.D., National University of Singapore (Singapore).
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