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December’s SLAS Technology Cover Article Features University of Wisconsin Research, “Automated System for Small-Population Single-Particle Processing Enabled by Exclusive Liquid Repellency”
Next month’s SLAS Technology features the cover article, “Automated System for Small-Population Single-Particle Processing Enabled by Exclusive Liquid Repellency,” outlining research led by Chao Li, Ph.D., (University of Wisconsin-Madison, USA). In the article, Li and his team describe how they combined a robotic liquid handler, an automated microscopic imaging system and real-time image-processing software for single-particle identification to create an automated platform using exclusive liquid repellency (ELR) microdrops for single-particle isolation, identification and retrieval.
December's SLAS Discovery Showcases Part Two of the Special Issue "Membrane Proteins: New Approaches to Probes, Technologies and Drug Design"
The December issue of SLAS Discovery features part two of the two-part special issue, "Membrane Proteins: New Approaches to Probes, Technologies and Drug Design."
In this issue, Guest Editor Veli-Pekka Jaakola, Ph.D., (Confo Therapeutics, Belgium) includes a series of articles focused on new screening tools and assays that find new chemical matter for medically relevant membrane protein targets. In addition, an overview of a new and emerging protein-lipid reconstitution methodology methodology utilizing Styrene Maleic Acid (SMA) polymers is featured.
November’s SLAS Technology Auto-Commentary, "On the Way to Efficient Analytical Measurements: The Future of Robot-Based Measurements," highlights potentially suitable replacement measurement systems and processes as outlined in the book, Automation Solutions for Analytical Measurements: Concepts and Applications.
SLAS has selected 53 life sciences students to receive SLAS Tony B. Academic Travel Awards. Award winners will present their research at the SLAS 2020 International Conference and Exhibition in San Diego, CA, USA, January 25-29, 2020.
Oak Brook, IL – October's SLAS Discovery features part one of a two-part special issue on "Membrane Proteins: New Approaches to Probes, Technologies and Drug Design." Part two of this special edition will be featured in December.
Oak Brook, IL – In the October Special Issue of SLAS Technology, Guest Editors Soojung Claire Hur, Ph.D., and Deok-Ho Kim, Ph.D., (Johns Hopkins University; Baltimore, MD, USA) introduce a collection of articles and reviews focused on the advancement in technologies that are playing a major role in shifting healthcare closer to more predictive, preventative and personalized medicine.
Oak Brook, IL – In “Rapid Single-Cell Microbiological Analysis: Toward Precision Management of Infections and Dysbiosis” authors Hui Li, Ph.D., and Pak King Wong, Ph.D., (The Pennsylvania State University, PA, USA), Michael Morowitz, Ph.D., (University of Pittsburgh, PA, USA) and Neal Thomas, Ph.D., (Penn State University, PA, USA) describe their development of a novel technology approach designed to help clinicians better manage bacterial infection diagnosis and treatment, reduce the improper use of antibiotics and limit the spread of drug-resistant organisms.
In September’s SLAS Discovery cover article, “Using Physicochemical Measurements to Influence Better Compound Design,” authors Robert J. Young, Ph.D., Shenaz B. Bunally, Ph.D., and Chris N. Luscombe, Ph.D., (GlaxoSmithKline) outline commonly used physiochemical properties and how they are assessed and measured throughout the drug discovery process, while also explaining the implications of each property that have led to flawed results. This review also offers suggestions on which contemporary methods can be used to improve subpar testing outcomes.
SLAS and Messe München Shanghai Co., Ltd., a wholly-owned subsidiary of Messe München in China, have announced a formally established a strategic partnership. SLAS will act as a supporter of the 2019 labtech China Congress hosted by Messe München Shanghai. SLAS will co-organize the SLAS Life Science Forum and jointly create the 200-square meter international Life Science Live Laboratory (Live Lab).
August’s edition of SLAS Discovery showcases research from James Woods, a fourth-year undergraduate student in biochemistry at Brigham Young University (BYU) (Utah). In “Selection of Functional Intracellular Nanobodies,” Woods describes current nanobody selection methods and focuses on those that ensure intracellular functionality. Nanobodies are recombinant antibody fragments derived from camelids that have a wide variety of potential uses.
The August edition of SLAS Technology features the cover article, “Technologies for the Directed Evolution of Cell Therapies,” a review featured in the journal’s March 2019 edition. The research, led by Dino Di Carlo, Ph.D., (University of California Los Angeles) highlights how the next generation of therapies are moving beyond the use of small molecules and proteins to using whole cells.
The Society for Laboratory Automation and Screening announced the winners of its annual New Product Awards at the SLAS Europe Conference and Exhibition held in Barcelona, Spain.
In a just-released SLAS Technology auto-commentary, “Peripheral Focused Ultrasound Stimulation (pFUS): New Competitor in Pharmaceutical Markets?” lead researchers on a recent study on noninvasive sub-organ ultrasound stimulation published in Nature Communications, highlight their use of focused ultrasound stimulation within peripheral organs to activate autonomic nerve circuits for its potential therapeutic effects.
In July’s SLAS Discovery feature article Tijmen H. Booij, Ph.D., Screening Specialist for NEXUS Personalized Health Technologies (Switzerland), discusses the switch from using 2D to 3D cell cultures in drug discovery to more accurately mimic human physiological conditions and improve the success rates of drugs in the early stages of preclinical drug discovery.
The Society for Laboratory Automation (SLAS) (Oak Brook, IL) and One Nucleus (London, UK) have teamed up to provide greater knowledge-sharing and connectivity opportunities to their members by collaborating on several in-person and online educational initiatives.
The recognition is part of the IUPAC’s 100th anniversary celebration and honors a diverse group of 118 outstanding younger chemists from around the world who embody the mission and core values of IUPAC including fostering worldwide communications in the chemical sciences and in uniting academic, industrial and public sector chemistry in a common language.
The June issue of SLAS Technology features the article, “Next Generation Compound Delivery to Support Miniaturized Biology,” which focuses on the challenges of changing the established screening paradigm to support the needs of modern drug discovery. The article also leads this special collection on The Science of Sample Management: Enabling Discovery from Bench to Clinic, based on content from SLAS 2018 Americas Sample Management Symposium.
The latest SLAS Discovery issue features the cover article, “A Perspective on Extreme Open Science: Companies Sharing Compounds without Restriction” by Timothy M. Willson, Ph.D., (University of North Carolina and Structural Genomics Consortium), is now accessible through June 20.
SLAS is pleased to announce the hiring of Christine Diedrich to the role of Publishing Manager. Diedrich will oversee all aspects of publishing for both SLAS’s peer-reviewed journals, SLAS Discovery and SLAS Technology, including planning, budgeting and operations.
The 2018 SLAS International Conference and Exhibition has been recognized by Trade Show Executive Magazine as a recipient of its annual “Fastest 50” and “Next Fastest 50” Awards.
SLAS is honored to announce Carine Nemr, Ph.D. candidate from the University of Toronto (Canada), as the 2019 SLAS Graduate Education Fellowship Grant recipient. This is the fourth year the SLAS grant has been awarded and Nemr is the first recipient from Canada.
The April edition of SLAS Technology features a special collection of articles prepared by biomedical and chemical engineering students at the University of Southern California (Los Angeles, CA, USA) that illustrate the growing use of nucleic acids for gene augmentation.
The April cover article of SLAS Discovery features “Addressing Antimicrobial Resistance through New Medicinal and Synthetic Chemistry Strategies,” by Monika I. Konaklieva, Ph.D., an online ahead-of-print article first published in December 2018.
In a new SLAS Technology auto-commentary the authors of “Analytical Measurements and Efficient Process Generation Using a Dual-Arm Robot Equipped with Electronic Pipettes,” highlight and discuss the main findings of their novel integration of electronic piston pipettes into an automation system using a dual-arm robot to perform liquid handling tasks similar to human operators.
The SLAS Discovery and SLAS Technology editors and editorial boards, in partnership with SAGE Publishing, announced their annual achievement award winners at a special reception at the SLAS 2019 International Conference and Exhibition earlier this month.
A full list of this year's SLAS2019 science and technology award winners is now available. Each year SLAS recognizes several award winners who represent the best of the Society's programs and mission. This year, eight awards and $15,000 in cash were given out.
SLAS recognized Cristian Soitu, M.Eng. and Ph.D. Candidate at University of Oxford, with the SLAS Innovation Award at SLAS2019 International Conference and Exhibition in Washington, DC. Soitu received the award as recognition of his exceptional podium presentation on Microfluidic Chambers Using Fluid Walls for Cell Biology.
Three New Product Award winners were announced on Tuesday, February 5, at a special press conference held at the SLAS International Conference and Exhibition in Washington, DC.
A new review by researchers from the University of Calabria (Italy) explores OCTNs, a small but intriguing group of transporters that are opening new frontiers in drug design research for improving drug delivery and predicting drug-drug interactions.
The SLAS Technology Ten annually showcases ten individual articles that stand out as the most innovative scientific achievements published in SLAS Technology in the past 12 months.
A new collection of reviews and original research articles in SLAS Technology illustrate how new technologies and advanced cell culture are accelerating basic research, drug discovery and drug development.
SLAS is happy to announce the promotion of Amy Wilkinson, CMP, to Director, Global Events. Wilkinson will direct the overall planning, management and execution of all of the Society’s educational programs, including two annual international conferences and quarterly topical and regional symposia.
SLAS is pleased to announce the Board of Directors approved the slate of candidates for the 2019 Board of Directors at its November meeting. Each new board member will join the SLAS Board of Directors for three-year terms beginning at SLAS2019, February 2-6, in Washington, DC.
A new study published ahead-of-print by SLAS Discovery describes an evaluation of microplate-based high-throughput cellular thermal shift assay (CETSA HT) performed at AstraZeneca to assess its suitability and reliability for application to early drug discovery campaigns.
A study in the December 2018 issue of SLAS Technology demonstrates the feasibility of using a steady-state/lifetime fluorescence plate reader for direct optimization of challenging formulation conditions and highlights the importance of performing formulation optimization under commercially relevant conditions.
Researchers from the University of Manchester (United Kingdom) explore recent developments and strategies for targeting the NLRP3 inflammasome as a potential therapeutic target in acute and chronic neurological and neurodegenerative diseases, and offer perspective on how this field may develop in the future.
SLAS, the Society for Laboratory Automation and Screening, has selected 50 students from 12 countries to present their research at SLAS2019 as the most recent winners of the SLAS Tony B. Academic Travel Award. These notable undergraduate students, graduate students, post-doctoral researchers and junior faculty members were selected by an independent panel of judges who evaluated their abstract proposals based on scientific merit and potential impact of the research toward the advancement of life sciences discovery and technology.
A new auto-commentary looks at how an emerging area of artificial intelligence, specifically the analysis of small systems-of-interest specific datasets, can be used to improve drug development and personalized medicine.
The internet of things (IoT) is allowing scientists to optimize laboratory operations and combine instruments to measure and respond to complex experimental conditions. As a result, IoT is enabling more detailed and more complex experimental designs.
A new review in SLAS Discovery explores how improved safety screening strategies and methods are improving the pharmaceutical discovery and development process. The authors outline several fundamental methods of the current drug screening processes and emerging techniques and technologies that promise to improve molecule selection. In addition, the authors discuss integrated screening strategies and provide examples of advanced screening paradigms.
Michael Tarselli, Ph.D., will join the Society for Laboratory Automation and Screening (SLAS) as its new Scientific Director, beginning September 1.
A new special issue of SLAS Discovery reflects examples of the recent groundswell of creative new applications for high-throughput flow cytometry (HTFC) in drug discovery.
Technologies that are reducing costs and changing the ways in which researchers and clinicians process and use therapeutic cells are showcased in the August 2018 special issue of SLAS Technology.
A time-resolved fluorescence resonance energy transfer-based BTK occupancy assay measures target engagement in peripheral blood mononuclear cells (PBMCs) and in lymph-node and bone-marrow samples.
To aid in the discovery and understanding of lncRNA biology, newly published work features the technological platforms and methodology presently used to identify the roles of lncRNA in biology. This work highlights the databases and tools used to study lncRNA and techniques used to study their function.
SLAS has selected Kelci Schilly, a graduate research assistant in the Department of Chemistry at the University of Kansas (Lawrence, KS, USA), as the inaugural recipient of the 2018 SLAS Visiting Graduate Researcher Grant, and will cover her three-month visit to the laboratory of SLAS President Sabeth Verpoorte, Ph.D., at the University of Groningen (The Netherlands).
A new SLAS Discovery review article summarizes new methods of fragment-based lead discovery (FBLD) to identify new compounds as potential antibiotics. It explains how FBLD works and illustrates its advantages over conventional high-throughput screening.
A new SLAS Discovery review article by GlaxoSmithKline researchers in the U.S. and U.K. offers an informative guide to the established and emerging tools available for early drug discovery and screening, and provides illustrative scenarios demonstrating considerations that drive decisions on choice of lead discovery tactics.
New research describes the development of a novel screening platform with automated production of 3D muscle- and tendon-like tissues using 3D bioprinting.
Researchers at Coyne Scientific (Atlanta, GA) share perspective about Clinical Trials in a Dish (CTiD), a novel strategy that bridges preclinical testing and clinical trials.
New research highlights a diversity of approaches that automated high-throughput flow cytometry has enabled for phenotypic drug discovery.
The June 2018 special issue of SLAS Technology provides a meaningful glimpse into the potential and applicability of quantitative imaging as life sciences and biomedical research move into an era of big data and high-content experiments.
The June issue of SLAS Discovery features two special collections of articles that address important trends for the advancement of life sciences R&D. Both collections include robust editorials by the guest editors, offering informed thoughts about the challenges and opportunities presented by these influential topics.
This vision of simplifying disease diagnosis using topically-applied nanotechnology could change the way skin diseases such as abnormal scars are diagnosed and managed.
In a new SLAS Discovery auto-commentary, two authors of an article recently published in eLife (“LINE-1 Protein Localization and Functional Dynamics During the Cell Cycle”) explain their general views on their novel discoveries and discuss ideas on the relevant new questions generated by their data.
A multidisciplinary team of scientists share recent advancements in innovative in-vitro cancer biology methods for screening drug-like molecules in cancer tissue relevant models in a new report published online ahead-of-print at SLAS Discovery. Entitled Advanced Development of Primary Pancreatic Organoid Tumor Models for High-Throughput Phenotypic Drug Screening, the report can be accessed for free.
Santosh Paidi, a graduate research assistant in the Department of Mechanical Engineering and at Johns Hopkins University, has been selected as the 2018 recipient of the SLAS Graduate Education Fellowship Grant. The $100,000 SLAS fellowship grant, awarded over two years, allows Paidi to continue his work in the lab of Ishan Barman, Ph.D., which employs vibrational spectroscopy and recent improvements in areas such as optics, nanotechnology and computing, to develop improved diagnostic tools that can provide rapid, robust, quantitative and molecular-specific readouts from biological specimen.
A new original research report available ahead-of-print at SLAS Technology demonstrates the semi-automation of a GlycoWorks RapiFluor-MS (RFMS) Kit using a pipetting robot to improve life sciences research productivity.
In the April 2018 issue of SLAS Technology, Breitwieser and colleagues of the Karlsruhe Institute of Technology (Germany) describe a fully automated high-throughput sorting system for zebrafish embryo phenotypes that benefits high-throughput screening by saving time and improving accuracy.
A review article by Prof. Stefan Broer, Ph.D., highlights opportunities and challenges in using amino acid transporters as drug targets. Amino Acid Transporters as Disease Modifiers and Drug Targets provides an overview of methods used to identify new inhibitors for amino acid transporters and outlines cell and organ function where these can be used to modulate, prevent or to treat diseases.
A perspective article in the March 2018 issue of SLAS Discovery from the biology group at the European Screening Centre Newhouse details how the European Lead Factory (ELF), a large publicly accessible drug discovery platform, uses microscale thermophoresis (MST) to aid in the prioritization of small molecule hits from high-throughput screening.
SLAS Discovery (formerly the Journal of Biomolecular Screening) and SLAS Technology (formerly the Journal of Laboratory Automation), both published by SLAS (Society of Laboratory Automation and Screening) in partnership with SAGE Publishing, hosted a special reception to celebrate the 2018 SLAS Journal Achievement Award honorees on Feb. 6 at SLAS2018, the SLAS International Conference and Exhibition, held Feb. 3-7, 2018, in San Diego, CA.
Three organizations earned a SLAS New Product Award yesterday at SLAS2018 in San Diego for their innovative new productsthat have played an important role in the advancement of life sciences drug discovery and development.
SLAS2018 was all about science and innovation as new keynote lectures, cutting-edge podium presentations and the new SLAS Ignite Theater series stoked the collaborative nature of today's life sciences professionals with three days of ground-breaking presentations that left attendees pondering new ways to keep pace with the speed of science.
A phenotypic high-throughput screen to identify modulators that improve mutant cystic fibrosis transmembrane conductance regulator (CFTR) activity is described in the SLAS Discovery February 2018 front cover feature article by Giuliano and colleagues of Proteostasis Therapeutics, Inc. (Cambridge, MA).
“The 2018 SLAS Technology Ten represent some of the most innovative scientific achievements that were featured in SLAS Technology in the past 12 months,” says Editor-in-Chief Edward Kai-Hua Chow, PhD (National University of Singapore).
Life sciences professionals and business development dealmakers from all walks of industry, academia and government have a new interchange at SLAS2018 – SLAS Ignite, a series of programs that foster scientific innovation through collaboration, debuts at the 2018 SLAS International Conference and Exhibition (SLAS2018), Feb. 3-7, in San Diego, CA.
A new article in the February 2018 issue of SLAS Technology describes a new platform that could change the way cancer is diagnosed and treated by automating the isolation of circulating tumor cells (CTCs) directly from cancer patient blood. This article provides unique insight into the development of a commercial system that has the potential to change the standard of care in cancer diagnosis and treatment.
A new original research article in SLAS Discovery presents a fast, sensitive, and robust methodology for screening small molecule inhibitors against CD73/Ecto-5’-Nucleotidase, a promising target for developing anti-cancer drugs.
This new (and freely available) original research article presents a fast, robust and accurate methodology for correlating compound identity to CYP1A2 potency of inhibitors in metabolic mixtures. The methodology is centered around an at-line nanofractionation platform in which a metabolic mixture is chromatographically separated followed by parallel on-line mass spectrometric (MS) analysis and at-line nanofractionation on high-density microtiter well plates that are then directly exposed to a bioassay.
An original research report by Eun Jeong Cho et al. (University of Texas at Austin) in the January 2018 Issue of SLAS Discovery presents a newly designed biochemical assay that is rapid, sensitive, inexpensive, and high-throughput screening (HTS)-friendly to identify antagonist against aldolase A (ALDOA).
A new methodology enables the investigation of a large number of structurally conserved enzymes belonging to the Fe(II)/2-oxoglutarate-dependent dioxygenase superfamily.
SLAS Discovery marks the 30th anniversary of Matrix Assisted Laser Desorption/Ionization Time of Flight (MALDI TOF), the soft ionization technique for analyzing non-volatile biomolecules using mass spectrometry, with a special issue showcasing 10 new research reports.
A review article in the December 2017 issue of SLAS Technology provides important information for life sciences and technology professionals in academia and industry and members of the general public who are interested in antibiotic resistance, general microbial detection principles, in vitro diagnostics, micro- and nanotechnologies, and next generation rapid microbial testing methods.
A new SLAS Technology review article by researchers at the University of Southern California and the University of California, Los Angeles, sheds light on the growing number and more sophisticated designs of theranostic nanoparticles.
SLAS is pleased to announce the addition of Emilio Diez Monedero, Peter Brian Simpson and Severine Tamas-Lhoustau to the Society's Board of Directors. They begin three-year terms in February 2018.
A new SLAS Discovery article available for free ahead-of-print enables researchers to derive more clinically-relevant information from 3D cell culture models.
Discovering new drugs has never been easy and some potential drug targets have historically been viewed as too challenging and thus off limits for prosecution. In a new SLAS Discovery review, authors John S. Lazo et al. of the University of Virginia reflect on the nature of protein tyrosine phosphatases and explores reasons why these enzymes have been eschewed by drug hunters, and how the landscape is beginning to change.
A new report shows how microsystems can be used to understand processes in heart tissue in detail and to test newly developed compounds applied in the treatment of cardiac diseases.
An exploration of the latest understanding of the complex mechanisms behind OA pain offers new possibilities and potential treatment targets for osteoarthritis (OA) pain. New areas of research discussed include the use of combination therapies and the development of biomarkers to target effective pain treatment.
The August 2017 issue of SLAS Technology (formerly the Journal of Laboratory Automation) showcases 10 new reviews and original research reports that illustrate how the progression of research assays from qualitative outputs toward increasingly sensitive quantitative outputs is transforming life sciences and biomedical research and diagnostics by improving the ability of researchers and clinicians to detect and quantify increasingly complex assays.
Information generated by screening tools, readily available therapies and potential pathways to drug development are the cornerstone of informed clinical research and clinical trial design. In a new review in the August 2017 issue of SLAS Discovery (formerly the Journal of Biomolecular Screening), authors Eric Chevet, Ph.D., of Inserm U1242 (Rennes, France) et al. analyze the recent literature and review the impact of unfolded protein response (UPR) in health and disease.
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