Clinical Platforms and Translational Models

Tuesday, April 16 • 4:10 p.m. – 5:30 p.m.

This session delves into the role of organoids and 3D multicellular models in drug discovery and clinical applications. We'll spotlight the use of 3D diagnostics alongside organoids in clinical and pre-clinical settings. Discussions will center on physiologically relevant disease models, integrating organoids, stroma, and isogenic pairs. We'll conclude with the alignment of molecular profiling (Omics) with in-vitro and in-vivo studies to enhance clinical efficacy predictions and utilize clinical results to inform further pre-clinical inquiry. 

Session Chairs:

Herve Tiriac, Ph.D. (University of California San Diego)

Maryam Rahman, M.D. (University of Florida)

Speakers:

Bently Doonan, M.D., M.S. (University of Florida Health)
3D Modelling Challenges and Opportunities in Cutaneous Malignancies

Alice Soragni, M.S., Ph.D. (UCLA)
Patient-Derived 3D Tumor Organoid Models of Rare Cancers for Precision Medicine

Leighton Elliott, M.D., M.S. (University of Florida)
Development of a Novel mRNA Lipid Particle Vaccine for Rhabdomyosarcoma Using Tumor Spheroids